Pharmacologic doses of glucocorticoids lower resistance to infection; the patient may be predisposed to systemic infections during, and for a time following, therapy.
Pharmacologic supraphysiologic doses of exogenous corticosteroids produce hypothalamic-pituitary-adrenal HPA axis suppression via a negative feedback mechanism, i. Dosages for local injections e.
Cortisone and prednisone are inactive until metabolized to the active metabolites hydrocortisone and prednisolone, respectively. A phenothiazine may be administered if necessary; lithium also has been recommended. The corticosteroid should be administered concurrently with appropriate antituberculosis chemotherapy.
For treatment of congenital adrenal hyperplasia, suppression of corticotropin secretion is required to decrease hypersecretion of adrenal androgens. IM403 Prednisolone Primary: In addition, it is thought that corticosteroids may help in the treatment of patients with blood disorders, such as multiple myeloma.
Explore Apps. However, for some diseases, such as childhood nephrotic syndrome, therapy may be initiated with alternate-day dosing.
It is classified as a glucocorticosteroid. Get Email Updates.
Corticosteroids Systemic This monograph includes information on the following: Long-term therapy may be required. For example, by decreasing swelling around tumors in the spine, brain, or bone, it can decrease the pressure of the tumor on nerve endings and relieve pain or other symptoms caused by the pressing tumor.
However, these agents may suppress transcription of mRNA in some cells e. IM403 Budesonide Primary: Contact your health care provider immediately , day or night, if you should experience any of the following symptoms: Poorly soluble derivatives—Slowly but completely absorbed. For glucocorticoid effects: Primarily by renal excretion of inactive metabolites.
They decrease synthesis and increase degradation of protein in lymphoid tissue, connective tissue, muscle, and skin. For long-term therapy, a short-acting agent cortisone or hydrocortisone or an intermediate-acting agent methylprednisolone, prednisolone, prednisone, or triamcinolone is recommended.
In idiopathic nephrotic syndrome, long-term therapy may be required to prevent frequent relapses. Administration of sodium as dietary salt and fluids also is required. Long-term use is not recommended.