The total therapeutic insulin concentration insulin glargine and its metabolites found in type 1 diabetic patients was markedly lower than what would be required for a half maximal occupation of the IGF-1 receptor and the subsequent activation of the mitogenic-proliferative pathway initiated by the IGF-1 receptor.
Store your pen with the pen cap on. Needles are not included in the pack. If this occurs, patients should increase the frequency of checking their blood glucose levels and might need to administer additional insulin.
Dependent on your daily dose and prescription insurance coverage. Hepatic impairment In patients with hepatic impairment, insulin requirements may be diminished due to reduced capacity for gluconeogenesis and reduced insulin metabolism.
All rights reserved. Active ingredient insulin glargine.
Patients should be aware of circumstances where warning symptoms of hypoglycaemia are diminished. This information is intended for use by health professionals. When given intravenously the elimination half-life of insulin glargine and human insulin were comparable. The time of occurrence of hypoglycaemia depends on the action profile of the insulins used and may, therefore, change when the treatment regimen is changed.
Clear colourless solution. Grip and squeeze the widest part of the outer needle cap, then turn your pen several times with your other hand to remove the needle. Re-use of needles increases the risk of blocked needles which may cause underdosing or overdosing see section 4. Work closely with your doctor to see if any increase is needed.
You can inject your dose here, here, or here. Nervous system disorders. To bookmark a medicine you must sign up and log in.
Get medical help right away if you have:. Baseline mean Adjusted mean change from baseline. Keep pens and needles out of the reach of children. Keep the pre-filled pen in the outer carton in order to protect from light.
Instruct patients to perform a safety test as described in Step 3 of the Instructions for Use. And of course, it's at no cost to you. That makes total sense.
I knew there was a reason why I liked you. Packs of 1, 3, 6 2 packs of 3 and 9 3 packs of 3 pens are available.
Toujeo is the only once-daily, long-acting insulin that has a 900-unit pen. Insulin label must always be checked before each injection to avoid medication errors between Toujeo and other insulins see section 6.